This chapter examines the future of higher education in the context of the emerging University 4.0 paradigm and the potential role of advanced artificial intelligence (AI) and IT competency models in shaping this future. The University 4.0 represents a new educational paradigm that aims to leverage cutting-edge technologies to enhance the learning experience of students and improve the efficiency of universities. The chapter begins by providing an overview of the University 4.0 system and its potential benefits and challenges. It then introduces the concept of AI and IT competency models and explores their potential applications in higher education. The chapter presents a detailed analysis of the potential impact of AI and IT competency models on various aspects of higher education, such as student learning outcomes, faculty productivity, operational efficiency, and institutional competitiveness. The analysis is based on a review of relevant literature and case studies of universities that have implemented these technologies.