Present investigation entitled “Influence of herbicides and varieties on growth, yield and quality of Paddy (Oryza sativa L.)” has been proposed to execute the field trial at the research farm, Department of Agronomy, AKS University Satna (M.P.). during the kharif season of 2020-21. The study consisted of four herbicides H0 – Control, H1 - Butachlor @1kg/ha at 3 DAT, H2 - Pyrazosulfuron ethyl 10% WP @ 150g/ha on 3-4 DAT, H3 - Bispyribac sodium @ 50g/ha, with three variety V1- IR-64, V2 - JR-206, V3 - JR-81. The field experiment was laid out in Randomized Block Design with a factorial concept with three replications. The results revealed that the herbicides, use of H1 (Butachlor @ 1 kg/ha) brought significant improvement in control of weed. It may be concluded that paddy variety (IR-64) brought significantly superior crop growth, yield and quality. Application of herbicide, Butachlor @1kg/ha and variety IR-64 (H1V1) demonstrated a more practical approach in reducing the impact of weeds and promoting improved crop growth with plant height (91.62 cm), number of tillers per plant (15.95), Grain yield (5169 kg/ha). Hence it could be concluded that the application of Butachlor @ 1 kg/ha with IR–64 variety highest could be applicable for Butachlor @ 1 kg/ha are most suitable herbicide for obtaining high rice grain yield and yield profitable strategies.