Liver cirrhosis is a significant health concern, prompting research into traditional remedies for liver protection. This study aims to elucidate the mechanisms by which the ethanolic extract of Curcuma longa (CLRE) exerts its hepatoprotective effects. The results indicated that treatment with CLRE significantly reduced histopathological damage and liver biochemistry markers compared to control groups. The extract promoted apoptosis in liver cells while inhibiting their proliferation, without affecting hepatic CYP2E1 levels. The findings assert that Curcuma longa's liver-protective properties benefits are due to its antioxidant and anti-inflammatory properties, potentially inhibiting the progression of liver cirrhosis and preserving liver function.