Global clinical researchers have identified India as a potential place of subjects where research can be conducted even without rigid compliance with regulatory norms. This has led to many controversies about the efficacy of clinical trial in India. It also put question mark on the practice and working of authorities involved with under Indian regulatory mechanism. This research paper aims at understanding the root cause of non-compliance of the clinical trial phases. It will also analyze the gaps of ground realties and functional requirement. An evaluation shall also be done to understand is it the demand of patient or requirement new disease is responsible for such events. This paper also explores the remedies thereto. The researcher has notices that there are numerous government-funded medical and pharmaceutical institutions with state-of-the-art facilities are the major reason for India being the targeted destination for clinical trial. However, to rule out any misuse independent institutional review boards should be formed, and a system should be created to enable these boards to share information about trials they have rejected and their reasons for doing so.