The COVID-19 pandemic has significantly altered the landscape of education, particularly for college students who transitioned from traditional in-person learning to remote education. This study explores the impact of the pandemic on students’ academic performance and mental well-being. Using a mixed-methods approach, including surveys and online interviews with 500 college students, the research identifies key challenges related to online learning, such as technological access, engagement and motivation. Additionally, the study highlights the mental health effects of social isolation and academic pressure. The results indicate a decline in academic performance and increased levels of stress, with students expressing a preference for hybrid learning models in the future. These findings suggest that educational institutions should focus on improving digital access, mental health support and hybrid learning strategies to better support students during and after global crises.