An ethnobotanical plant survey was conducted to explore the medicinal plant knowledge and their uses in the study area. The exploration of the ethnomedicinal survey includes 56 plant species belonging to 48 genera of 32 families practiced by the people of Kuchanur, Theni district, Tamil Nadu, India. The traditional knowledge of people having reliable ethnomedicinal expertise in the drug’s formulation using available plants and its dosage practiced were documented. The suitable data were collected through questionnaires as well as informal personal interviews during the field trips in the study area. These data were documented from Jan 2022 to May 2022. The collected therapeutic plants were used to cure skin ailments, jaundice, diabetes, headache, migraine, urinary infection, wounds, and kidney ailments. The curative plants used by the Kuchanur people are systematized sequentially, by their plant name, family name, nearby name(s), part(s) utilized, method of treatment, and their relating illness were documented. The conservation of the ethnomedicinal practices as well as the plants are needed in order to cope up with the predominant illness. This has made us to revert the people’s life back to the natural way of healing practice for the health enrichment in the future.