Herbal-based drugs are gaining popularity and are becoming an important part of the primary healthcare system. The current study aimed to assess the anthelmintic activity of Pongamia pinnata leaves against Pheritima posthuma and Haemonchus contortus. Five different concentrations (5, 15, 25, 50, and 75 mg/ml) of water-soluble, acetone, petroleum ether, and methanol extracts were evaluated on worms. It comprised determining the time of paralysis (P) and death (D) of the worms. The acetone extract showed more significant effects on paralyzing the worms than other investigated extracts. The impact of extracts on the paralysis and death of the Pheritima posthuma, as evidenced by the results, acetone > petroleum ether > methanol > aqueous. Similarly, among all the extracts obtained from Pongamia pinnata, acetone extract required the shortest time to cause death and paralysis of Haemonchus contortus, followed by petroleum ether < methanol < aqueous extracts. Albendazole was employed as a reference standard medicine, and saline water was used as the usual control.. The leaf extracts of Pongamia pinnata revealed a good remedy for worm infections and in-vitro trials proved its anthelmintic properties at higher doses.