India’s healthcare system faces challenges such as inadequate infrastructure, a shortage of medical personnel, and accessibility disparities between urban and rural regions. E-health initiatives, including telemedicine, mobile health applications, and digital health records, offer a solution to improve healthcare accessibility, affordability, and efficiency. Despite promising developments like the Ayushman Bharat Digital Mission and e-Sanjeevani, significant obstacles remain, such as poor internet connectivity, low digital literacy, data privacy issues, and fragmented healthcare systems. Addressing these challenges requires investments in digital infrastructure, robust data protection policies, interoperability across platforms, and public-private partnerships. Technologies like AI, block-chain, etc can further enhance healthcare delivery. A collaborative approach that prioritises cultural and linguistic diversity while ensuring stakeholder engagement will be essential to creating a scalable, inclusive e-health ecosystem, thereby working towards achieving universal healthcare coverage in India.