This study explores the Stereoselective Synthesis of Complex Organic Molecules. Stereoselective synthesis is a pivotal technique in organic chemistry that focuses on the selective formation of specific stereoisomers in the synthesis of complex organic molecules. Given that the spatial arrangement of atoms in a molecule can significantly influence its chemical behavior and biological activity, achieving high stereoselectivity is essential, particularly in pharmaceutical development. This synthesis approach is critical for generating compounds with desired therapeutic effects while minimizing side effects associated with undesired stereoisomers. The key strategies employed in stereoselective synthesis include asymmetric synthesis using chiral catalysts and auxiliaries, stereospecific reactions, and retrosynthetic analysis. Asymmetric synthesis enables the preferential formation of one enantiomer over another, while stereospecific reactions can convert one stereoisomer into a specific product without generating other forms. Retrosynthetic analysis serves as a blueprint for deconstructing complex molecules into simpler precursors, ensuring that stereochemical outcomes are integrated into the synthetic planning process. Recent advances in machine learning and biocatalysis are transforming the landscape of stereoselective synthesis.