Abstract: Food hygiene and acceptability remain central to global health agendas, especially in developing countries like India where the interplay of traditional practices and rapid modernization poses unique challenges. The discourse on food hygiene is multifaceted, encompassing microbial hazards, chemical contaminants, and more recently, the environmental impact of food production and waste. The World Health Organization emphasizes that safe food supplies support national economies, trade, and tourism, and underpin sustainable development. In India, with its diverse culinary practices and socio-economic disparities, ensuring food hygiene extends beyond regulatory compliance to encompass cultural acceptability and environmental sustainability. Addressing food hygiene and acceptability in the context of food waste re-usage requires a holistic approach that integrates regulatory frameworks, technological innovations, and consumer education. The potential of food waste reuse to contribute to food security and sustainability in India is immense, provided that safety and quality concerns are adequately addressed. Innovative technologies and processes that ensure the safety of food products derived from waste, coupled with effective consumer engagement strategies, can play a pivotal role in transforming food waste from a problem into a solution. The significance of this research lies in its attempt to bridge the gap between food safety, food acceptability, and food waste reusage in India. By exploring the regulatory, technological, and social dimensions of this nexus, the study aims to provide insights that can inform policy, practice, and consumer behaviour towards achieving a more sustainable and food-secure future. The challenges are manifold, but so are the opportunities for innovation and change. However, this study has also uncovered significant challenges that impede the adoption and implementation of food waste reuse initiatives, including technological limitations, infrastructure deficiencies, and a general lack of awareness among the public and businesses about the potential of food waste. These challenges call for targeted interventions, ranging from policy reforms and infrastructure development to public awareness campaigns and investment in technology, to create an enabling environment for food waste reuse.