Vermicompost, the product of the decomposition of organic matter by earthworms, has emerged as a promising solution for plant disease management. This organic amendment not only enhances soil fertility and structure but also contributes to the suppression of plant pathogens through various mechanisms. Vermicompost is rich in beneficial microorganisms, including bacteria, fungi, and actinomycetes, which compete with and inhibit the growth of plant pathogens. It also contains bioactive compounds such as enzymes, antibiotics, and hormones that bolster plant immune responses and directly antagonize pathogens. Furthermore, vermicompost improves soil physical properties, promoting healthy root growth and reducing the susceptibility of plants to diseases. Research has demonstrated significant reductions in disease incidence and severity in crops treated with vermicompost, highlighting its potential as an eco-friendly, sustainable alternative to chemical pesticides. This paper reviews the current knowledge on the role of vermicompost in plant disease management, elucidating its mechanisms of action, benefits, and potential applications in integrated pest management strategies.