Fusarium oxysporum f. sp. lycopersici is a devastating fungal pathogen responsible for Fusarium wilt in tomatoes, leading to significant yield losses worldwide. This review provides a comprehensive examination of the biology, pathogenicity, and control strategies for this pathogen. The biology section explores the pathogen's life cycle, genetic diversity, and the mechanisms underlying its ability to infect and colonize tomato plants. In discussing pathogenicity, we delve into the virulence factors, host-pathogen interactions, and environmental conditions that exacerbate disease progression. Control strategies encompass an array of methods including cultural practices, resistant cultivars, chemical treatments, and biological control agents. Advances in molecular techniques and genetic engineering offer new avenues for developing disease-resistant tomato varieties and effective biocontrol methods. Integrated disease management approaches, combining multiple strategies, are emphasized as the most sustainable solution for managing Fusarium wilt. This review highlights the need for ongoing research and collaboration among scientists, breeders, and growers to develop and implement effective control measures against F. oxysporum f. sp. lycopersici.