The advent of novel food packaging materials, including biodegradable plastics, edible films, and nanocomposites, presents opportunities to enhance environmental sustainability and reduce food waste. However, the chemical safety of these emerging materials is critical to ensure they do not compromise nutritional health. This study examines the chemical safety of innovative food packaging materials and their implications for human health. It reviews recent advancements in packaging technologies, focusing on their chemical composition, potential migration of substances into food, and resultant health impacts. The analysis includes an evaluation of regulatory standards, testing methodologies, and risk assessment frameworks to identify potential hazards associated with packaging materials. Special attention is given to the release of nanoparticles, additives, and residual monomers, which may interact with food products and affect their nutritional value. The study also explores the impact of these interactions on food safety, considering both acute and chronic exposure scenarios. The findings underscore the need for stringent safety evaluations and regulatory measures to protect consumers from potential health risks. By addressing these concerns, the research aims to provide a comprehensive understanding of how emerging food packaging materials influence nutritional health and offer recommendations for improving safety protocols and guidelines.