Abstract: Micronutrients are vital for maintaining optimal health, yet their effectiveness is often limited by their bioavailability—the extent to which they are absorbed and utilized by the body. This paper examines how chemical formulations of micronutrients influence their bioavailability. The solubility, stability, and interaction of micronutrients with other dietary components are significantly affected by their chemical form. For instance, water-soluble vitamins like Vitamin C are generally more readily absorbed than less soluble forms, while minerals such as calcium exhibit varying absorption rates based on their chemical form, with calcium citrate showing higher bioavailability compared to calcium carbonate. Stability during digestion and interaction with dietary inhibitors also play critical roles in absorption. Innovations such as nanoencapsulation and chelation have shown promise in enhancing the bioavailability of micronutrients by improving solubility and reducing interactions with absorption inhibitors. Understanding these factors is crucial for optimizing micronutrient formulations and addressing deficiencies effectively. This paper highlights the importance of chemical formulation in micronutrient bioavailability and provides insights into developing more effective nutritional supplements and fortification strategies for better health outcomes.