SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES ON SCHIFF BASE DERIVED FROM 2-AMINO 4,6- DIHYDROXYPYRIMIDINE AND BENZALDEHYDE AND ITS COBALT COMPLEXES

Abstract

In this work, the heterocyclic Schiff bases ligand derived from 2-amino-4,6-dihydroxypyrimidine with Benzaldehyde (L) was synthesized. The ligand used to synthesis complexes of Co(II). The synthesized compounds have been characterized by FT-IR, 1H-NMR and UV-Vis techniques for the ligands and FT-IR, UV-Vis, all reactions monitored by TLC, molar conductivity and magnetic susceptibility measurements for the corresponding complexes. The conductance measurements in DMSO showed that the Co(II) complex was 1:2 electrolytes respectively. The ligand and its complexes were screened for their antifungal and antibacterial activity against Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme and Aspergllus flavus and Escherichia coli, Salmonella typhi, Staphylococcus aureus, B. subtilis. The result indicated that the complexes exhibited good antifungal and antibacterial activities.