Evaluation of the effect of Synbiotic in High-fat diet and streptozotocin induced diabetes in Wistar rats

Abstract

Background: Dysbiosis is the causative factor chronic diseases including diabetes, obesity, cancer, and Inflammatory Bowel disease. Homeostasis of gut flora with prebiotics and probiotics could reduce the risk factors of chronic disease. Aim: To study the effect of Synbiotic (combination of prebiotics and probiotics) in a High-fat diet and STZ-induced diabetes in Rats. Methods and Material: In the present study we had designed the formulation containing sauerkraut juice as a good source of probiotics and prebiotics (Allium Sativum and Cucurbita maxima). The designed polyherbal formulation (PHF) in lower and higher concentrations was evaluated for antidiabetic and antiobesity activity in a High-fat diet and Streptozotocin-induced diabetes in Wistar rats. Results: Polyherbal formulation in lower concentration (PHF-LC) and Polyherbal formulation in high concentration (PHF-HC) reduced blood glucose significantly (p