CRUDE PLANT EXTRACTS' POTENTIAL ANTI-DIABETIC EFFECTS

Abstract

Background:The aim of this study was to evaluate the anti-diabetic effect of the aqueous and alcoholic extracts on alloxan-induced diabetic mice. Methods: Following an acute toxicity test, alloxan was used to cause diabetes in Swiss albino mice for scientific purposes. The study examined the two-week fasting mean blood glucose level in normal, diabetic mice that were not treated, and diabetic mice that were treated with alcoholic and aqueous extracts. Version 20 of the Statistical Package for the Social Sciences was used to statistically analyse the data. A P-value of less than 0.05 was deemed statistically noteworthy. Results:Steroids, phenolic compounds, flavonoids, and terpenes were found in the extracts after phytochemical screening, and these substances may have an impact on the extracts' anti-diabetic properties. However, anthraquinones and alkaloids were absent from the extracts. Conclusion: The aqueous extract (200 mg/kg) showed the highest percentage reduction in blood glucose levels and the ability of Hibiscus syriacus extracts in reducing blood glucose levels presumably due to the presence ofantioxidant constituents such as flavonoids.