FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF CINNARIZINE

Abstract

Crosecarmellose Crospovidone, and pregelatinized starch were among the superdisintegrants used in varying concentrations to make the fast- disintegrating cinnarizine tablets using direct compression method. Because magnesium stearate stuck to punches and dies, coground mixes of crospovidone and magnesium stearate were made in a ball mill to increase the stability and compatibility of the final product. The FTIR and DSC analyses demonstrated compatibility of the employed polymer and cinnarizine. As the concentration of superdisintegrants increases, the diintegration time decreases. Of all the formulations, the one using hypromellose as a superdisintegrant meets all the requirements to a satisfactory degree.