IN-VIVO STUDY OF POLYHERBAL FORMULATION AGAINST ANTITUBERCULAR DRUGS INDUCED HEPATOTOXICITY

Abstract

Formulations containing polyherbal ingredients are frequently utilized to preserve the liver and cure hepatic dysfunction and regeneration. They can also increase hunger and guard against harm to the gastrointestinal system. The current study's goal was to evaluate the in-vivo hepatotoxicity caused by antitubercular medication formulations. This study examines the hepatotoxicity of isoniazid (INH) and rifampicin (RIF) administered to rat kidneys, as well as the mitigating effects of a polyherbal formulation. Rats were given oral doses of polyherbal extract in addition to INH and RIF to render them drunk. The effect on histopathology was examined in the kidneys of rats. Rats that were not treated exhibited deviation, but after receiving treatment, their weight remained normal. However, the rats receiving polyherbal therapy were able to keep their biochemical indices close to normal. According to histopathological findings, there was not enough INH and RIF-induced hepatotoxicity to cause appreciable tissue damage. Rat kidneys that have received treatment or not show abnormal architecture as a result. In summary, rat kidneys treated with polyherbal medicine are shielded against the hepatotoxic effects of RIF and INH.