Synthesis and Antibacterial Activity of Novel Dehydrodiisoeugenol Derivatives

Abstract

Dehydrodiisoeugenol constitute a new group of antimitotic and potential anti-cancer agents that inhibit tubulin polymerization. It is a dihydrobenzofuranoid type neolignan have been synthesized and diversified to its respective ether using conventional method (K2CO3/R-Br/acetone; R = alkyl, aralkyl) and characterized by 1H NMR, IR, elemental analysis and mass spectral data. These synthesized compounds were screened for their potential antibacterial activity against Gram-positive and Gram-negative bacteria. Few of them displayed promising antibacterial activity. All these compounds were new and confirmed by Scifinder search.