Investigations on Hematotoxic and Nephrotoxic Analysis in Aniline Induced Wistar Rats.

Abstract

The Nephrotoxic and Hematotoxic risks of aniline have been identified and evaluated in the current investigation using male Wistar rats. Aniline was administered orally to Group A rats for 30 days using gavage at a dose of 20 mg/kg body weight per day, while Group B rats received standard saline water as treatment. After the completion of treatment, the male Wistar rats were sacrificed for specialized tests. Serum biomarkers of kidney injury, creatinine and blood urea increased their concentration. Sodium and potassium concentrations decreased and histological changes such as random apical sloughing of the brush border of proximal tubular cells occurred. Proximal and distal tubular cells exhibited marked degenerative changes.