This study examines the gastro protective activity of ethanolic leaf extract ofCassia grandis Linn against aspirin induced peptic ulcers on swiss albino wistar rat. Oral aspirin treatment (300 mg/kg body weight) caused ulceration. Omeprazole (standard) was given to swiss albino wistar rats at a dose of 20 mg/kg body weight, and Cassia grandis Linn was given at doses of 200 and 400 mg/kg body weight once daily for 14 days prior to the development of ulcers. Gastric secretions parameters were assessed after the experiment