A Study on Assessment of Anti-inflammatory Activity of Ethanolic Extracts of Tamarind (Tamarindus indica) Seeds

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs in the world today to treat inflammatory conditions. The NSAIDs used in the inflammatory conditions do not cure and remove the underlying cause of the disease but they only modify the inflammatory response to the diseases. Therefore, there is resurgence to search for new antiinflammatory agents. Current study was conducted with the main purpose of evaluating the anti-inflammatory activity of the ethanolic extracts of seeds of Tamarindus indica. Anti-inflammatory activity of ethanolic extracts of seeds of T. indica at doses of 250 mg/kg, 500 mg/kg and 750 mg/kg was evaluated in Wistar albino rats in carrageenan induced paw edema animal model test. Inflammation was produced by administering 0.1 ml of 1% carrageenan into sub-plantar surface of rat hind paw to negative control group; 250 mg/kg (Group-A), 500 mg/kg (Group-B), 750 mg/kg (Group-C) ethanolic extracts of seeds of T. indica and Diclofenac sodium 10 mg/kg (positive control) was administered orally respectively, Results inferred that there was statistically significant (p