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RESEARCH PAPER
Year : 2015  |  Volume : 4  |  Issue : 1  |  Page : 64-76

Protective role of Aloe Vera wine against oxidative stress induced by salmonella infection in a murine model


Department of Microbiology, Panjab University, Chandigarh, India

Correspondence Address:
Sanjeev Kumar Soni
Department of Microbiology, Panjab University, Chandigarh
India
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Source of Support: None, Conflict of Interest: None


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In this study, we have used Aloe vera gel supplemented with cane sugar as a substrate for the production of functional fermented Aloe vera based herbal wine. We evaluated the protective role of Aloe vera wine against Salmonella induced oxidative stress in a murine model. Oral administration of Aloe vera wine exhibited antibacterial activity against S. Typhimurium leading to its significant clearance from liver, spleen and intestine of the infected group. Restoration of liver-function enzyme alanine aminotranferase (ALT), aspartate aminotransferase (AST) levels and improved hepatic histoarchitecture in the infected wine–fed group indicated the protective efficacy of Aloe vera wine. Furthermore, the Aloe vera wine administration reduced hepatic lipid peroxidation, increased the superoxide dismutase activity and reduced glutathione levels indicating improved resistance to oxidative stress. In parallel, infected mice administered with Aloe vera wine exhibited a 41.1% increase in the ferric reducing antioxidant power (FRAP) plasma levels compared to infected counterpart which is suggestive of an improved antioxidant status in the wine fed mice. Morphological changes in the cells of S. Typhimurium in the presence of Aloe vera wine was observed by scanning electron microscopy (SEM) which provided qualitative information of the change in its morphology when treated with Aloe vera wine. These observations suggest that Aloe vera wine has the potential to modulate the changes induced by Salmonella infection and exerts protective effect against generated oxidative stress; however, further investigations are required to explore its complete mechanism of action.


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