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RESEARCH PAPER
Year : 2015  |  Volume : 4  |  Issue : 1  |  Page : 28-33

Effect of eumicrotremus orbis water extracts on the expression of proteins related to lipid metabolism in obese mice


1 Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul; Division of Metabolism and Functionality Research, Korea Food Research Institute, Seongnam, Korea
2 Division of Metabolism and Functionality Research, Korea Food Research Institute, Seongnam, Korea
3 Jeonbuk Institute for Bioindustry, Jeonju, Korea
4 Division of Marine Food Bioscience & Technology, Gangneung National University, Gangneung, Korea
5 Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Korea

Correspondence Address:
Byoung-Mok Kim
Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul; Division of Metabolism and Functionality Research, Korea Food Research Institute, Seongnam
Korea
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Source of Support: None, Conflict of Interest: None


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In this study, the lipolytic and anti-obesity effects of Eumicrotremus orbis water extracts (EOWE) were investigated in mice. Animals were randomized into three groups: CON (not supplemented with EOWE); SIL (low dose of supplemented EOWE); SIH (high dose of supplemented EOWE). The AST, ALT, and ALP serum levels were reduced in the EOWE groups compared to the CON group, with no significant difference (p < 0.05). There was a decrease in serum TG levels in the SIH group compared to the CON group (p<0.05). The HSL and p-HSL expression in the EOWE groups were increased compared to the CON group (p<0.05). The expression of MCAD in all organs of the EOWE groups were increased compared to the CON group (p<0.05). There was an increase in the UCP-2 expression in liver and muscle tissues of the EOWE groups, compared to the CON group (p<0.05). These results suggested that EOWE acts as a PPARa activator, and may regulate obesity by stimulating PPARa and UCP activity. Therefore, EOWE appeared to show potential as an anti-obesity material.ax


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