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RESEARCH PAPER
Year : 2015  |  Volume : 4  |  Issue : 1  |  Page : 182-194

Gender specific association of angiotensinogen gene polymorphisms with essential hypertension


1 Department of Molecular Biology, Regional Medical Research Centre; School of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneswar, Odisha, India
2 Department of Medicine, Capital Hospital, Bhubaneswar, Odisha, India
3 Department of Medicine, VSS Medical College, Burla, Odisha, India
4 Clinical Division, Regional Medical Research Centre, Bhubaneswar, Odisha, India
5 Department of Molecular Biology, Regional Medical Research Centre, Bhubaneswar, Odisha, India

Correspondence Address:
Manoranjan Ranjit
Department of Molecular Biology, Regional Medical Research Centre, Bhubaneswar, Odisha
India
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Source of Support: None, Conflict of Interest: None


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Hypertension is a rapidly emerging pathophysiological condition caused by both genetic and environmental factors responsible for widespread morbidity and mortality and angiotensinogen is a key polypeptide in blood pressure physiology. In the present study M235T, T174M and G-6A polymorphisms of angiotensinogen gene have been studied in context of hypertension. Adult patients/hypertensives (n=246) and controls/normotensives (n=274) were enrolled. Their anthropometric, lifestyle data and blood samples were collected. Lipid profiling and genotyping were carried out. The parameters those were found to be higher in hypertensives compared to normotensives in the total group are alcohol consumption (p<0.001) and triglyceride levels (p=0.031). In males, M allele of M235T polymorphism (p<0.001), G allele of G-6A polymorphism (p=0.001) and alcohol consumption (p<0.001) and in females, the T allele of M235T polymorphism (p=0.005) and M allele of T174M polymorphism (p=0.003) were significantly high in the patient groups than the respective control groups. All the three polymorphisms were strongly linked to each other, the M235T and T174M being the most tightly linked (Total: D'=0.9987, p<0.0001, r2= 0.4498; Males: D'=0.8828, p<0.0001, r2=0.4200; females: D'=0.3890, p=0.0019, r2=0.0592) followed by M235T and G-6G (Total: D'=0.9975, p<0.0001, r2=0.5427; Males: D'=0.8553, p<0.0001, r2=0.5747; females: D'=0.4614, p=0.0012, r2=0.4837) and the least between T174M and G-6A (Total: D'=0.9985, p<0.0001, r2=0.0110; Males: D'=0.9220, p<0.0001, r2=0.0120; females: D'=0.3558, p=0.0087, r2=0.0132). The TMG haplotype in the total population (p=0.0036) and females (p=0.0039) and the MTG haplotype in males (p=0.0042) were identified as risk haplotypes. The angiotensinogen gene polymorphisms were found to exert gender-specific effects on blood pressure regulation and hypertension pathophysiology.


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