Energy conservation is obtained through energy savings. One such method to attain energy conservation is the use of nanofluids in place of conventional fluids. In the present paper, the effect of working fluid on the thermophysical properties of Silicon Carbide (SiC) suspensions is determined experimentally. The thermohydraulic performance of these suspensions is investigated using a Double pipe heat exchanger (DPHE). Three different working fluids, viz., Distilled Water (DW), a mixture of Ethylene glycol and water in the ratios of 20:80 and 40:60 (20:80 EG-Water and 40:60 EG-Water) are considered to prepare SiC nanofluid in the volume concentration ranging from 0.02% to 0.08%. The experiments are conducted in the turbulent regime. For the same volume concentration of SiC suspensions, a significant enhancement in thermophysical properties, particularly in viscosity and thermal conductivity and hence in the thermo-hydraulic performance is observed for both EG-Water based SiC nanofluids, compared to that of DW based nanofluid. The heat transfer coefficient of DW based nanofluid is 1.21 times that of 40:60 EG-Water based nanofluid and 1.05 times than that of 20:80 EG-Water based nanofluid for a volume concentration of 0.08%, over the range of flow rates considered in the analysis. Even, the Thermal Performance Factor values of three nanofluids also vary by marginal difference. This shows that for the three different base fluids considered in the analysis, the effect of base fluid is observed to be less significant when a high thermal conductivity nanoparticles like SiC are used to prepare the corresponding nanofluids.