Introduction: Menopausal can be exiting yet uncomfortable time in a women life. Which is treated natural supplements one of the foods for prevention menopausal symptoms are the sesame seeds. The aim of the present study to assess the effectiveness sesame seeds to improving post-menopausal symptoms among age between 55-65 years. Research Methodology: A quantitative research approach with a True experimental design was adopted and conducted at Ariyankuppam, Puducherry. The Simple random sampling technique was used to study group 30 and 30 control group. The conceptual frame work selected for this study is Wiedenbach‟s Helping Art of Clinical Nursing Theory (1964). Data was collected using self-structured questionnaires. Demographic variable, assessment of post-menopausal symptoms and clinical variables. Results: The pretest mean score of symptoms in the study group was 26.30±5.74 and the posttest mean score of symptoms in the study group was 19.07±5.29. The mean difference score was 7.23. The calculated paired‘t’ test value of t = 9.021 was statistically significant at p<0.001 level. Conclusion: The level of menopausal symptoms was significantly reduced for study group after providing sesame powder.